![]() ![]() Lycopene interventions were highly variable (supplement with or without food, based as tomato juice/paste/raw product, or combined with olive oil), the dose ranged from 1.44 to 75 mg lycopene/d and was not reported in 11 of 43 included studies. Pooled analysis was conducted using outcomes with available data. The Cochrane Risk-of-Bias tool was used to assess the quality of the included papers. ![]() Intervention trials assessing dietary or supplemental lycopene on CVD outcomes were included. Using the PRISMA guidelines, 4 databases were systematically searched from inception: Medline, Cinahl, Proquest, and Scopus. The aim of this systematic review and meta-analyses is to determine the efficacy of consuming dietary and/or supplemental lycopene on cardiovascular risk factors. Lycopene, a carotenoid with high antioxidant capacity, may be protective. Cardiovascular disease (CVD) is the leading cause of death globally and the presence of ≥1 cardiovascular risk factors elevates total risk.
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